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课题组简介
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课题组基本信息
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王悦桐（PI助手）
<p class="MsoNormal" style="line-height: 150%; margin: 0pt"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 16pt; font-weight: bold; mso-fareast-font-family: 楷体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">1<font face="楷体">、</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">景永奎教授课题组：</font></span></b></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">本课题组主要研究方向为抗肿瘤新药物作用靶点的确认、癌细胞分化诱导剂和凋亡促进剂的寻找及其机制研究。建立了以肿瘤特异性分子靶标研究新型抗癌药物的技术平台，从事抗肿瘤活性指导下天然活性化合物的提取分离、结构修饰。在新抗肿瘤活性化合物的发现以及联合用药法案的建立方面取得了突出的成绩，发现了多个药物候选活性化合物。在《</font>Blood<font face="宋体">》、《</font><font face="Times New Roman">Leukemia</font><font face="宋体">》、《</font><font face="Times New Roman">Clinical Cancer Research</font><font face="宋体">》、《</font><font face="Times New Roman">Cancer Research</font><font face="宋体">》等学术刊物上发表学术论文</font><font face="Times New Roman">130</font><font face="宋体">余篇，被他引</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">40</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">00<font face="宋体">多次。申请发明专利</font><font face="Times New Roman">24</font><font face="宋体">项，取得国际专利</font><font face="Times New Roman">4</font><font face="宋体">件，中国专利</font><font face="Times New Roman">16</font><font face="宋体">件。主持</font><font face="Times New Roman">10</font><font face="宋体">项美国</font><font face="Times New Roman">NIH</font><font face="宋体">和癌症研究基金会支持项目。先后两次获得国家自然科学基金海外青年学者合作研究基金资助，参与</font><font face="Times New Roman">6</font><font face="宋体">项重大新药创制科技重大专项课题、</font><font face="Times New Roman">6</font><font face="宋体">项国家自然科学基金等国家级项目的研究工作。</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <!--?xml:namespace prefix="o" ns="urn:schemas-microsoft-com:office:office" /--> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; margin: 0pt; mso-list: l1 level1 lfo1"><span style="font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">2、</span></span><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">主持或参加科研项目（课题）及人才计划项目情况</font></span></b><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">：</font></span></b><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></b></p> <p class="15" style="line-height: 150%; margin: 0pt; mso-char-indent-count: 0.0000; mso-list: l0 level1 lfo2"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">1.<span> </span></span></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项，</font><font face="Times New Roman">2017ZX09101002-007</font><font face="宋体">，抗多药耐肿瘤新青蒿素衍生物</font><font face="Times New Roman">DHX-11</font><font face="宋体">的临床前研究，</font><font face="Times New Roman">2017/03-2020/12</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">，参与。</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000; mso-list: l0 level1 lfo2"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">2.<span> </span></span></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金面上项目，</font>31570350<font face="宋体">，藤黄属植物中作用于</font><font face="Times New Roman">PI3K/Akt/mTOR</font><font face="宋体">通路的抗前列腺癌活性成分及作用机制研究，</font><font face="Times New Roman">2016/01-2019/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">3. </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Samuel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Waxman</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Cancer</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Research</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">foundation<font face="宋体">资助项目，</font><font face="Times New Roman">Development of</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">α,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">β-unsaturated</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">carbonyl</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">compounds</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">as</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">novel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">anti-leukemia</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">agents<font face="宋体">，</font><font face="Times New Roman">201</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">/07-201</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">/06</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">，主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项，</font><font face="Times New Roman">2012ZX09103-101-023</font><font face="宋体">，抗多药耐药肿瘤新药</font><font face="Times New Roman">DHX-11</font><font face="宋体">的研究与开发，</font><font face="Times New Roman">2012/01-2015/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">5.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金，</font>81072533<font face="宋体">，</font><font face="Times New Roman">JZY03</font><font face="宋体">及其类似物的抗癌作用机理和构效关系研究，</font><font face="Times New Roman">2011/01-2013/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">6.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金项目海外及港澳学者合作研究基金项目，</font>81028015<font face="宋体">，</font><font face="Times New Roman">c-FLIP</font><font face="宋体">作为取代环戊酮类抗肿瘤活性化合物的分子靶标的研究，</font><font face="Times New Roman">2011/01-2012/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">7.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家科技部国际科技合作项目，</font>2009DFA31200<font face="宋体">，基于特异性分子靶标的抗肿瘤药物筛选平台的建立与新型抗肿瘤药物的开发，</font><font face="Times New Roman">2009/01-2011/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">8.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项</font><font face="Times New Roman">“</font><font face="宋体">十一五</font><font face="Times New Roman">”</font><font face="宋体">课题，</font><font face="Times New Roman">2009ZX09103-080</font><font face="宋体">，新型抗肿瘤活性化合物</font><font face="Times New Roman">PTZ-09</font><font face="宋体">的研究与开发，</font><font face="Times New Roman">2009/01-2011/03</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; margin: 0pt; mso-list: l1 level1 lfo1"><span style="font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">3、</span></span><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">代表性论文：</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></b></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(1)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Rui</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Wang,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ying</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Li,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ping</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Gong,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Janice</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Gabrilove,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Samuel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Waxman</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">and</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing. Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Myeloid Leukemia Cells</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">. </span><span><a title="Molecular cancer therapeutics." href="https://www.ncbi.nlm.nih.gov/pubmed/29959200"><span style="font-family: Calibri; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Mol Cancer Ther.</span></a></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">2018 Sep;</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">17(9):1871-1880</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">2</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ping Gong</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Kun Li</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ying Li</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Dan Liu</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Linxiang,Zhao,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui,Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">HDAC and Ku70 axis-an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue. Cell Death and Disease,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(2018)9:623</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">3</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> ; Lijuan Xia; Janice Gabrilove; Samuel Waxman;Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Sorafenib inhibition of Mcl-1 accelerates ATRA induced apoptosis in differentiationresponsive AML cells Clinical Cancer Research 2016.3.1 22(5): 1211~1221</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(4) Guyue Liu</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Rui Wang; Yuetong Wang; Pengzhan Li; Guisen Zhao; Linxiang,Zhao; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">，</font></span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1<font face="宋体">，</font><font face="Times New Roman">Molecular Cancer Therapeutics,2013.9 12(9):1837~1847</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(5) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> ; Lijuan Xia; Janice Gabrilove; Samuel Waxman;Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">apoptosis in acute myeloid leukemia cells,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Leukemia 2013.2,27(2)</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(6) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Changda Liu; Lijuan Xia; Guisen Zhao; Janice Gabrilove;Samuel Waxman; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase P1-1,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Clinical Cancer Research, 2012.12.15,18(24):</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">6690~6701</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">7</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yang X, Liu G, Li H, Zhang Y, Song D, Li C, Wang R, Liu B, Liang W, Jing YK, Zhao G. Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation. J Med Chem. 2010</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">53:1015-22</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">8</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Min Lu</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Lijuan Xia; Huiming Hua; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Acetyl-keto-beta-boswellic acid induces apoptosis through a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">death receptor 5-mediated pathway in prostate cancer cells, Cancer Research,</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">2008.2.15, 68(4): 1180~1186</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Chunmin Li; Dandan Song; Guisen Zhao; Linxiang Zhao; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Ethacrynic Acid Butyl-Ester Induces Apoptosis in Leukemia Cells through a Hydrogen Peroxide–Mediated Pathway Independent of Glutathione S-Transferase P1-1 Inhibition, Cancer Research, 2007.8.15, 67(16): 7856~7864</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">10</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Chen D, Chan R, Waxman S, Jing YK. Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of JNK and upregulation of death receptors. Cancer Research, 2006 66:11416-23</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">11</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lijuan Xia</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Elisa Wurmbach; Samuel Waxman; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Upregulati on of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis, Leukemia, 2006.3.30, 20(6): 1009~1016</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">12</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing Y</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">K</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Hellinger N, Xia L, Monks A, Sausville EA, Zelent A, Waxman S. Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Research, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">65:7847-55</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">13</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lu M, Mira-y-Lopez R, Nakajo S, Nakaya K and Jing YK. Evidence for a linear gene regulatory network linking estrogen receptor </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, retinoic acid receptor </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, and cellular retinoic acid binding protein II expression in human breast cells. Oncogene, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">24:4362-9</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">14</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Xia L, Chen D, Han R, Fang QC, Waxman S and Jing YK. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in acute myeloid leukemia. Molecular Cancer Therapeutics, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4:381-388</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">15</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lu M, Xia LJ, Luo D,Waxman S and Jing YK. Dual effects of glutathione-s-transferase </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">p </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis. Oncogene. 2004</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">23:3945-52</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">16</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Xia LJ, Lu M and Waxman S. The cleavage product ∆PML-RARa contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells. Oncogene 2003</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">22:4083-91</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(1</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">7</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Lijuan Xia; Samuel Waxman, Targeted removal of PML-RARα protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia, Blood, 2002.8.1, 100(3): 1008~1013</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">18</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Long Wang; Lijuan Xia; Guoqiang Chen; Zhu Chen;Wilson H. Miller; Samuel Waxman, Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo, Blood, 2001.1.1, 97(1): 264~269</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">19</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Dai J, Chalmers-Redman R.E, Tatton W.G., Waxman S. Arsenic trioxidase selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">peroxide-dependent pathway. Blood 1999</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">94:2102-2111</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">20</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Waxman S and Mira-y-Lopez R. The cellular retinoic acid-binding protein II (CRABPII) is a positive regulator of retinoic acid signaling in breast cancer cells. Cancer Research. 1997</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">57:1668-1672</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 24.1pt; margin: 0pt; mso-char-indent-count: 2.0000"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p> </o:p></span></b></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold; mso-fareast-font-family: 楷体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4<font face="楷体">、</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="楷体">实验室平台介绍：</font></span></b><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">本实验室注重研究抗肿瘤药物的</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">前沿领域，</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">有</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">浓厚的学术追求</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">氛围</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">和</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">严谨的</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">科研创新</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">态度，同时在学校</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">多学科交叉、融合的研究平台上</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">开拓多方向的科研探索思路。本</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">实验室</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">现有科研助理</font>1<font face="宋体">人，博士后</font><font face="Times New Roman">1</font><font face="宋体">人，</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">在读硕</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">、</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">博士生</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">共</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">计</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">18</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">人，定期举行一些团体活动，重视和支持每一位同学的爱好和兴趣发展。学术上的互帮互助，生活上的团结友爱，造就了我们向心力强</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">、</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">团结一致的课题组。</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">热忱</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">期待每一位热爱科研的同学加入！</font> </span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p> </o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">景永奎教授实验室电话：</font>024-23986975</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">E-</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">mail<font face="宋体">： </font><font face="Times New Roman">jingyk@syphu.edu.cn </font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">所招专业：</font> 100706<font face="宋体">药理学（博士）、</font><font face="Times New Roman">100706</font><font face="宋体">药理学（硕士）、</font><font face="Times New Roman">105504</font><font face="宋体">药学（药理学方向）（硕士） </font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <!--EndFragment-->
<p class="MsoNormal" style="line-height: 150%; margin: 0pt"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 16pt; font-weight: bold; mso-fareast-font-family: 楷体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">1<font face="楷体">、</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">景永奎教授课题组：</font></span></b></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">本课题组主要研究方向为抗肿瘤新药物作用靶点的确认、癌细胞分化诱导剂和凋亡促进剂的寻找及其机制研究。建立了以肿瘤特异性分子靶标研究新型抗癌药物的技术平台，从事抗肿瘤活性指导下天然活性化合物的提取分离、结构修饰。在新抗肿瘤活性化合物的发现以及联合用药法案的建立方面取得了突出的成绩，发现了多个药物候选活性化合物。在《</font>Blood<font face="宋体">》、《</font><font face="Times New Roman">Leukemia</font><font face="宋体">》、《</font><font face="Times New Roman">Clinical Cancer Research</font><font face="宋体">》、《</font><font face="Times New Roman">Cancer Research</font><font face="宋体">》等学术刊物上发表学术论文</font><font face="Times New Roman">130</font><font face="宋体">余篇，被他引</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">40</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">00<font face="宋体">多次。申请发明专利</font><font face="Times New Roman">24</font><font face="宋体">项，取得国际专利</font><font face="Times New Roman">4</font><font face="宋体">件，中国专利</font><font face="Times New Roman">16</font><font face="宋体">件。主持</font><font face="Times New Roman">10</font><font face="宋体">项美国</font><font face="Times New Roman">NIH</font><font face="宋体">和癌症研究基金会支持项目。先后两次获得国家自然科学基金海外青年学者合作研究基金资助，参与</font><font face="Times New Roman">6</font><font face="宋体">项重大新药创制科技重大专项课题、</font><font face="Times New Roman">6</font><font face="宋体">项国家自然科学基金等国家级项目的研究工作。</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <!--?xml:namespace prefix="o" ns="urn:schemas-microsoft-com:office:office" /--> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; margin: 0pt; mso-list: l1 level1 lfo1"><span style="font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">2、</span></span><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">主持或参加科研项目（课题）及人才计划项目情况</font></span></b><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">：</font></span></b><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></b></p> <p class="15" style="line-height: 150%; margin: 0pt; mso-char-indent-count: 0.0000; mso-list: l0 level1 lfo2"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">1.<span> </span></span></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项，</font><font face="Times New Roman">2017ZX09101002-007</font><font face="宋体">，抗多药耐肿瘤新青蒿素衍生物</font><font face="Times New Roman">DHX-11</font><font face="宋体">的临床前研究，</font><font face="Times New Roman">2017/03-2020/12</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">，参与。</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000; mso-list: l0 level1 lfo2"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">2.<span> </span></span></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金面上项目，</font>31570350<font face="宋体">，藤黄属植物中作用于</font><font face="Times New Roman">PI3K/Akt/mTOR</font><font face="宋体">通路的抗前列腺癌活性成分及作用机制研究，</font><font face="Times New Roman">2016/01-2019/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">3. </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Samuel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Waxman</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Cancer</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Research</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">foundation<font face="宋体">资助项目，</font><font face="Times New Roman">Development of</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">α,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">β-unsaturated</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">carbonyl</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">compounds</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">as</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">novel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">anti-leukemia</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">agents<font face="宋体">，</font><font face="Times New Roman">201</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">/07-201</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">/06</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">，主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项，</font><font face="Times New Roman">2012ZX09103-101-023</font><font face="宋体">，抗多药耐药肿瘤新药</font><font face="Times New Roman">DHX-11</font><font face="宋体">的研究与开发，</font><font face="Times New Roman">2012/01-2015/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">5.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金，</font>81072533<font face="宋体">，</font><font face="Times New Roman">JZY03</font><font face="宋体">及其类似物的抗癌作用机理和构效关系研究，</font><font face="Times New Roman">2011/01-2013/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">6.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家自然科学基金项目海外及港澳学者合作研究基金项目，</font>81028015<font face="宋体">，</font><font face="Times New Roman">c-FLIP</font><font face="宋体">作为取代环戊酮类抗肿瘤活性化合物的分子靶标的研究，</font><font face="Times New Roman">2011/01-2012/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">7.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">国家科技部国际科技合作项目，</font>2009DFA31200<font face="宋体">，基于特异性分子靶标的抗肿瘤药物筛选平台的建立与新型抗肿瘤药物的开发，</font><font face="Times New Roman">2009/01-2011/12</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">主持</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">8.</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">重大新药创制</font>”<font face="宋体">科技重大专项</font><font face="Times New Roman">“</font><font face="宋体">十一五</font><font face="Times New Roman">”</font><font face="宋体">课题，</font><font face="Times New Roman">2009ZX09103-080</font><font face="宋体">，新型抗肿瘤活性化合物</font><font face="Times New Roman">PTZ-09</font><font face="宋体">的研究与开发，</font><font face="Times New Roman">2009/01-2011/03</font><font face="宋体">，</font></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">参与</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">。</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; margin: 0pt; mso-list: l1 level1 lfo1"><span style="font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt"><span style="mso-list: Ignore">3、</span></span><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="楷体">代表性论文：</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></b></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(1)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Rui</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Wang,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ying</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Li,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ping</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Gong,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Janice</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Gabrilove,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Samuel</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Waxman</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">and</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing. Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Myeloid Leukemia Cells</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">. </span><span><a title="Molecular cancer therapeutics." href="https://www.ncbi.nlm.nih.gov/pubmed/29959200"><span style="font-family: Calibri; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Mol Cancer Ther.</span></a></span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">2018 Sep;</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">17(9):1871-1880</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">2</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ping Gong</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Kun Li</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ying Li</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Dan Liu</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Linxiang,Zhao,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui,Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">HDAC and Ku70 axis-an effective target for apoptosis induction by a new 2-cyano-3-oxo-1,9-dien glycyrrhetinic acid analogue. Cell Death and Disease,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(2018)9:623</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">3</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> ; Lijuan Xia; Janice Gabrilove; Samuel Waxman;Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Sorafenib inhibition of Mcl-1 accelerates ATRA induced apoptosis in differentiationresponsive AML cells Clinical Cancer Research 2016.3.1 22(5): 1211~1221</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(4) Guyue Liu</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Rui Wang; Yuetong Wang; Pengzhan Li; Guisen Zhao; Linxiang,Zhao; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">，</font></span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Ethacrynic acid oxadiazole analogs induce apoptosis in malignant hematologic cells through downregulation of Mcl-1 and c-FLIP, which was attenuated by GSTP1-1<font face="宋体">，</font><font face="Times New Roman">Molecular Cancer Therapeutics,2013.9 12(9):1837~1847</font></span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(5) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> ; Lijuan Xia; Janice Gabrilove; Samuel Waxman;Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">apoptosis in acute myeloid leukemia cells,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Leukemia 2013.2,27(2)</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(6) Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Changda Liu; Lijuan Xia; Guisen Zhao; Janice Gabrilove;Samuel Waxman; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase P1-1,</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Clinical Cancer Research, 2012.12.15,18(24):</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">6690~6701</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">7</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yang X, Liu G, Li H, Zhang Y, Song D, Li C, Wang R, Liu B, Liang W, Jing YK, Zhao G. Novel oxadiazole analogues derived from ethacrynic acid: design, synthesis, and structure-activity relationships in inhibiting the activity of glutathione S-transferase P1-1 and cancer cell proliferation. J Med Chem. 2010</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">53:1015-22</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">8</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Min Lu</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Lijuan Xia; Huiming Hua; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Acetyl-keto-beta-boswellic acid induces apoptosis through a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">death receptor 5-mediated pathway in prostate cancer cells, Cancer Research,</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">2008.2.15, 68(4): 1180~1186</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">9</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Rui Wang</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Chunmin Li; Dandan Song; Guisen Zhao; Linxiang Zhao; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Ethacrynic Acid Butyl-Ester Induces Apoptosis in Leukemia Cells through a Hydrogen Peroxide–Mediated Pathway Independent of Glutathione S-Transferase P1-1 Inhibition, Cancer Research, 2007.8.15, 67(16): 7856~7864</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">10</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Chen D, Chan R, Waxman S, Jing YK. Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of JNK and upregulation of death receptors. Cancer Research, 2006 66:11416-23</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">11</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lijuan Xia</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Elisa Wurmbach; Samuel Waxman; Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Upregulati on of Bfl-1/A1 in leukemia cells undergoing differentiation by all-trans retinoic acid treatment attenuates chemotherapeutic agent-induced apoptosis, Leukemia, 2006.3.30, 20(6): 1009~1016</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">12</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing Y</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">K</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, Hellinger N, Xia L, Monks A, Sausville EA, Zelent A, Waxman S. Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Research, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">65:7847-55</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">13</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lu M, Mira-y-Lopez R, Nakajo S, Nakaya K and Jing YK. Evidence for a linear gene regulatory network linking estrogen receptor </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, retinoic acid receptor </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">a</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">, and cellular retinoic acid binding protein II expression in human breast cells. Oncogene, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">24:4362-9</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">14</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Xia L, Chen D, Han R, Fang QC, Waxman S and Jing YK. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in acute myeloid leukemia. Molecular Cancer Therapeutics, 2005</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4:381-388</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">15</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Lu M, Xia LJ, Luo D,Waxman S and Jing YK. Dual effects of glutathione-s-transferase </span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">p </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">on As2O3 action in prostate cancer cells: enhancement of growth inhibition and inhibition of apoptosis. Oncogene. 2004</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">23:3945-52</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">16</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Xia LJ, Lu M and Waxman S. The cleavage product ∆PML-RARa contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells. Oncogene 2003</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">22:4083-91</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(1</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">7</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Lijuan Xia; Samuel Waxman, Targeted removal of PML-RARα protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia, Blood, 2002.8.1, 100(3): 1008~1013</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">18</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Yongkui Jing</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(#)(</span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">*</span><sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; vertical-align: super; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">) </span></sup><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">; Long Wang; Lijuan Xia; Guoqiang Chen; Zhu Chen;Wilson H. Miller; Samuel Waxman, Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo, Blood, 2001.1.1, 97(1): 264~269</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">19</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Dai J, Chalmers-Redman R.E, Tatton W.G., Waxman S. Arsenic trioxidase selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">peroxide-dependent pathway. Blood 1999</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">94:2102-2111</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="text-align: left; line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">(</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">20</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">)</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"> </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">Jing YK, Waxman S and Mira-y-Lopez R. The cellular retinoic acid-binding protein II (CRABPII) is a positive regulator of retinoic acid signaling in breast cancer cells. Cancer Research. 1997</span><span style="line-height: 150%; font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">, </span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">57:1668-1672</span><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 24.1pt; margin: 0pt; mso-char-indent-count: 2.0000"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 12pt; font-weight: bold; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p> </o:p></span></b></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><b><span style="line-height: 150%; font-family: 'Times New Roman'; font-size: 14pt; font-weight: bold; mso-fareast-font-family: 楷体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">4<font face="楷体">、</font></span></b><b><span style="line-height: 150%; font-family: 楷体; font-size: 14pt; font-weight: bold; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="楷体">实验室平台介绍：</font></span></b><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; text-indent: 21pt; margin: 0pt; mso-char-indent-count: 2.0000"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">本实验室注重研究抗肿瘤药物的</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">前沿领域，</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">有</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">浓厚的学术追求</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">氛围</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">和</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">严谨的</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">科研创新</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">态度，同时在学校</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">多学科交叉、融合的研究平台上</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">开拓多方向的科研探索思路。本</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">实验室</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">现有科研助理</font>1<font face="宋体">人，博士后</font><font face="Times New Roman">1</font><font face="宋体">人，</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">在读硕</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">、</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">博士生</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">共</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">计</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">18</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">人，定期举行一些团体活动，重视和支持每一位同学的爱好和兴趣发展。学术上的互帮互助，生活上的团结友爱，造就了我们向心力强</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">、</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">团结一致的课题组。</font></span><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">热忱</font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">期待每一位热爱科研的同学加入！</font> </span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p> </o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'"><font face="宋体">景永奎教授实验室电话：</font>024-23986975</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 宋体; font-size: 10.5pt; mso-bidi-font-family: 'Times New Roman'; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'; mso-ascii-font-family: 'Times New Roman'; mso-hansi-font-family: 'Times New Roman'">E-</span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'">mail<font face="宋体">： </font><font face="Times New Roman">jingyk@syphu.edu.cn </font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <p class="MsoNormal" style="line-height: 150%; margin: 0pt"><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"><font face="宋体">所招专业：</font> 100706<font face="宋体">药理学（博士）、</font><font face="Times New Roman">100706</font><font face="宋体">药理学（硕士）、</font><font face="Times New Roman">105504</font><font face="宋体">药学（药理学方向）（硕士） </font></span><span style="font-family: 'Times New Roman'; font-size: 10.5pt; mso-fareast-font-family: 宋体; mso-font-kerning: 1.0000pt; mso-spacerun: 'yes'"> <o:p></o:p></span></p> <!--EndFragment-->
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