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课题组基本信息

/__local/8/F9/C2/75E95C7CA69459E7B79E10A26A0_9C2B1CFD_ED17.jpg /__local/1/E4/C1/5FDEDE91C3994039ECD56F4629D_2CB792B6_79C4.jpg /__local/9/AA/2E/4C60E1F3E6AAA4036C6C549CE76_99B2EFFA_AA3E.jpg /__local/8/F9/C2/75E95C7CA69459E7B79E10A26A0_9C2B1CFD_ED17.jpg /__local/1/E4/C1/5FDEDE91C3994039ECD56F4629D_2CB792B6_79C4.jpg /__local/9/AA/2E/4C60E1F3E6AAA4036C6C549CE76_99B2EFFA_AA3E.jpg 陈丽霞陈丽霞

李华教授课题组——结构药理学与药物化学实验室简介： 
  
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李华教授课题组为结构药理学与药物化学实验室，由李华教授和陈丽霞教授共同组建。实验室配有微量热泳动仪（MST，用于直接测定小分子化合物和蛋白质的相互作用）、蛋白质结晶自   动化工作站（Gryphon）、AKTA高效蛋白质纯化仪（GE）、HPLC（Angilent和Waters）等多台大型先进仪器。具备进行计算机虚拟筛选和药物设计的高性能图形工作站集群，安装有ICM-Pro和AutoDock Vina、Phenix、CCP4、COOT等药物筛选和设计、蛋白质晶体学软件等。实验室成员在分子克隆、蛋白质表达与纯化、蛋白质机器的结构、功能与机制、细胞培养、膜蛋白结构生物学、药物筛选、天然产物分离和制备、药物合成、药效学和作用机制研究等方面具有丰富的经验与成果积累，发表了一系列国际一流的学术论文。 
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近年来，课题组在Science, Natural Product Reports, Journal of Experimental & Clinical Cancer Research, Oncotarget, Organic Chemistry Frontiers, Scientific Reports, Journal of Natural Products, European Journal of Organic Chemistry, Proteins, Journal of Biological Chemistry,　Journal of Molecular Biology等国际知名杂志上发表研究论文文章120余篇。其中，发表在国际顶级杂志Science上的文章，解析了高分辨率的钠钙交换蛋白的晶体结构，第一次在原子水平阐明了其进行离子交换的分子基础。同时，课题组获得<span lang="EN-US" style="line-height: 150%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 宋体; mso-bidi-theme-font: minor-bidi; mso-bidi-font-weight: bold">5项国家自然科学基金项目，以及多项省部级项目的资助。<span lang="EN-US" style="line-height: 150%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-bidi-theme-font: minor-bidi; mso-bidi-font-weight: bold"> 
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<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">　 <span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">课题组研究方向为<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast; mso-bidi-font-weight: bold">：<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">重大疾病相关蛋白质的结构生物学、基于结构的药物设计与发现、基于蛋白质结构的天然药物发现、靶点和作用机制研究。 
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<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">以人类重大疾病为靶标<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">特别是我国发病率高的疾病<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">例如结核病、糖尿病、神经退行性疾病和癌症等<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">开展结构生物学、药理学和药物化学等多学科交叉的研究，解析有关疾病病理或者病原微生物生理的重要蛋白质的晶体结构<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">以目标靶蛋白的结构为基础，从包括所有天然产物在内的化合物数据库中筛选先导化合物<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">并对先导化合物进行设计和结构改造<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-hansi-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast">，<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">最终获得有自主知识产权的新药候选者。 
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<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">联系方式：<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">电子邮件：5402118@qq.com<span style="line-height: 150%; font-family: 宋体; font-size: 12pt; mso-ascii-font-family: 'Times New Roman'; mso-bidi-font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; mso-fareast-theme-font: minor-fareast; mso-hansi-theme-font: minor-fareast">；syzyclx@163.com 
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