bet356体育在线育-欢迎莅临

当前位置：网站首页 > 师资队伍正文

课题组基本信息

/__local/B/56/E2/246839A95866029875A49BEA3C4_8F504979_112D5.jpg /__local/1/BF/26/D5F606974758191FC2D40398ACA_E8C6D1F0_D40D.jpg /__local/C/06/2E/52DC16FF2CB73018144AA366603_E35F1BBD_EAC6.jpg /__local/F/FD/FD/278A618457558470D602E9FD622_CC70F637_9959.jpg /__local/B/56/E2/246839A95866029875A49BEA3C4_8F504979_112D5.jpg /__local/1/BF/26/D5F606974758191FC2D40398ACA_E8C6D1F0_D40D.jpg /__local/C/06/2E/52DC16FF2CB73018144AA366603_E35F1BBD_EAC6.jpg /__local/F/FD/FD/278A618457558470D602E9FD622_CC70F637_9959.jpg

<div class="richContent"> 
 <h2 style="text-align: justify">课题组研究方向： </h2> 
 <h2 style="text-align: justify; text-indent: 37px">我们课题组多年来一直从事化学、生物学和药学等交叉学科研究工作，目前的兴趣是探索杯咔唑的化学生物学和药物化学。</h2> 
 <h2 style="text-align: justify; line-height: 150%; text-indent: 37px">理解小分子与生物学靶标之间相互作用的规律是上述研究中的核心问题，也是广义主客体化学的研究范畴。从最初的冠醚、环糊精，到目前的第三代主体分子杯芳烃、柱芳烃等，主客体化学至今已有近半世纪的历史。不断衍生的主体也丰富了客体的演化：从最初的阴阳离子，中性小分子到生物大分子。对后两者的识别和调控能力决定了主体分子成为药物载体以及先导药物分子的潜力。</h2> 
 <a style="line-height: 150%; font-family: 微软雅黑; color: rgb(102,102,102); font-size: 16px; font-weight: normal">
 <img alt=" " src="/__local/D/37/F1/3100EFDAD0D089225276C89CC9F_22166103_3F36.jpg?e=.jpg" style="width: 600px; float: none; height: 200px" vsbhref="vurl" vurl="/_vsl/D37F13100EFDAD0D089225276C89CC9F/22166103/3F36?e=.jpg" vheight=" 200px" vwidth=" 600px" orisrc="/__local/D/37/F1/3100EFDAD0D089225276C89CC9F_22166103_3F36.jpg?e=.jpg" class="img_vsb_content"></a> 
 
 <h3 style="text-justify: inter-ideograph; text-align: justify; margin-top: 10px; margin-bottom: 10px"></h3> 
 目前的杯芳烃大都基于苯酚骨架，受构像及尺寸大小等因素的限制，与生物大分子适配度不高。因此，尽管杯芳烃在材料等领域取得了巨大成功，在生物学以及药学等生命科学中的应用却步履蹒跚，进展缓慢。构建具有更大尺寸、更丰富构像、与生物大分子适配性能更好的新型杯芳烃，是该领域研究的重点与难点。鉴于此，我们课题组采用咔唑这一稠环芳烃为基本骨架，构建了空间结构更大、构像更加独特的新型大环分子（杯咔唑，见上图）。 
 <h3 style="text-justify: inter-ideograph; text-align: justify; margin-top: 10px; margin-bottom: 10px"> </h3> 
 
 <a style="color: blue">
 <img alt=" " src="/__local/0/37/4F/AE693E615DB6E96DED964328070_9ABA2847_4DFC.jpg?e=.jpg" style="width: 600px; float: none; height: 450px" vsbhref="vurl" vurl="/_vsl/0374FAE693E615DB6E96DED964328070/9ABA2847/4DFC?e=.jpg" vheight=" 450px" vwidth=" 600px" orisrc="/__local/0/37/4F/AE693E615DB6E96DED964328070_9ABA2847_4DFC.jpg?e=.jpg" class="img_vsb_content"></a> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">与传统的大环（见上图）相比，杯咔唑构像的可调范围更宽。其丰富的构像可以通过调节寡聚数目得以实现。如下图所见，杯[3]咔唑可形成一端封闭的锥形结构，其体积与钾离子通道大小相当；杯[4]咔唑可以形成中空的、类纺线锤形状的构象；而杯[5]、杯[6]等更高寡聚度咔唑大环的构像更加独特，目前仍在探索中。</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">另外，构成这些大环基本单元的咔唑，其自身也有许多独特的性质：它即是性能优异的荧光团，被广泛应用于生产染料、颜料、光电导体、感光材料等；也是天然生物碱的母核，其抗菌和抗肿瘤活性近年来也逐渐被发现和报道。咔唑自身的这些光电及生物性能也赋予了杯咔唑更加广泛的应用空间，值得深入地挖掘和探索。</h3> 
 <a>
 <img alt=" " src="/__local/F/22/E1/DF237EFBF1E58BB86F6AEB9C010_D1D77F0A_4A2A.jpg?e=.jpg" style="width: 600px; height: 550px" vsbhref="vurl" vurl="/_vsl/F22E1DF237EFBF1E58BB86F6AEB9C010/D1D77F0A/4A2A?e=.jpg" vheight=" 550px" vwidth=" 600px" orisrc="/__local/F/22/E1/DF237EFBF1E58BB86F6AEB9C010_D1D77F0A_4A2A.jpg?e=.jpg" class="img_vsb_content"></a> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">当前，我们对杯咔唑的化学生物学研究主要聚焦于探索其模拟酶活性以及对核酸的识别和调控作用。通过我们的努力，我们期待杯咔唑能大放异彩，最终成为：1. 具有抗肿瘤活性的大分子类先导药物；2.增进难溶性药物生物利用度的小分子载体；3.活体检测疾病靶点的光学试剂。</h3> 
 <h2 style="text-align: justify">发表论文：</h2> 
 <h1 style="text-align: justify">2011,3－至今（入职沈阳药科大学后）</h1> 
 <h1 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 0px; margin-left: 40px">1   Engineering 1,3-Alternate Calixcarbazole forRecognition and Sensing of Bisphenol F in Water</h1> 
          <a href="http://pubs.acs.org/author/Li%2C+Gang" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Gang Li</a>, <a href="http://pubs.acs.org/author/Zhao%2C+Liang" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Liang Zhao</a>, <a href="http://pubs.acs.org/author/Yang%2C+Peng" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Peng Yang</a><a href="http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03398#cor1" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">*</a>, <a href="http://pubs.acs.org/author/Yang%2C+Zhaozheng" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Zhaozheng Yang</a>, <a href="http://pubs.acs.org/author/Tian%2C+Zhangmin" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Zhangmin Tian</a>, <a href="http://pubs.acs.org/author/Chen%2C+Yan" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Yan Chen</a>, <a href="http://pubs.acs.org/author/Shen%2C+Hongyan" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Hongyan Shen</a>, and <a href="http://pubs.acs.org/author/Hu%2C+Chun" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Chun Hu</a><a href="http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03398#cor2" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">*</a> 
     Anal. Chem.(IF, 5.886)2016，DOI:10.1021/acs.analchem.6b03398 
       
 
 <img alt=" " src="/__local/9/8B/B4/D4B809417A59565DB5A31241593_B95E0ACF_AD32.gif?e=.gif" width="500" height="281" vsbhref="vurl" vurl="/_vsl/98BB4D4B809417A59565DB5A31241593/B95E0ACF/AD32?e=.gif" vheight="281" vwidth="500" orisrc="/__local/9/8B/B4/D4B809417A59565DB5A31241593_B95E0ACF_AD32.gif?e=.gif" class="img_vsb_content"> 
     
 2    Calix[3]carbazole:One-Step Synthesis and Host–Guest Binding 
          PengYang*, Yong Jian, Xue Zhou, Gang Li, Tuo Deng, Hongyan Shen, Zhaozheng Yang,Zhangmin Tian. 
 J. Org. Chem. (IF, 4.721). 2016, 81, 2974 
                 
 
 <img alt=" " src="/__local/B/DA/3E/83F5A36B6B34799F72A138BBB56_830CB3C3_3E2B.gif?e=.gif" width="500" height="135" vsbhref="vurl" vurl="/_vsl/BDA3E83F5A36B6B34799F72A138BBB56/830CB3C3/3E2B?e=.gif" vheight="135" vwidth="500" orisrc="/__local/B/DA/3E/83F5A36B6B34799F72A138BBB56_830CB3C3_3E2B.gif?e=.gif" class="img_vsb_content"> 
 
 3   <a href="http://www.sciencedirect.com/science/article/pii/S0925400514015500" style="color: blue">Adenosine triphosphateselective fluorescent turn-onresponse of anovel thiazole orange derivative via their cooperative co-assembly</a> 
     Tuo Deng,JianHui Chen, Hui Yu, Peng Yang*, Yong Jian, Gang Li, Xue Zhou, Hongyan Shen,Jianzhou Gui* 
     Sensors & Actuators B Chemical (IF, 4.758), 2015, 209, 735. 
       
 <a style="color: blue">
 <img alt=" " src="/__local/7/25/4D/6177B09CCCE3E0E61DC8B783FCE_BAEB6ED7_1BD17.png?e=.png" style="width: 600px; float: none; height: 400px" vsbhref="vurl" vurl="/_vsl/7254D6177B09CCCE3E0E61DC8B783FCE/BAEB6ED7/1BD17?e=.png" vheight=" 400px" vwidth=" 600px" orisrc="/__local/7/25/4D/6177B09CCCE3E0E61DC8B783FCE_BAEB6ED7_1BD17.png?e=.png" class="img_vsb_content"></a> 
 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">4  <a href="http://www.sciencedirect.com/science/article/pii/S0040403914018528" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Synthesis of a novelmethylene-bridged biscarbazole derivative and evaluation of its DNA andnucleotide binding properties</a></h3> 
          GangLi, Xue Zhou, Peng Yang*, Yong Jian, Tuo Deng, Hongyan Shen, Ying Bao. 
     Tetrahedron Lett. (IF, 2.380) 2014, 55, 7054. 
   
        <a>
 <img alt=" " src="/__local/7/BD/96/80B4EFD367D5B0171BC0FB4220C_9C614755_51B8.gif?e=.gif" style="width: 600px; height: 170px" vsbhref="vurl" vurl="/_vsl/7BD9680B4EFD367D5B0171BC0FB4220C/9C614755/51B8?e=.gif" vheight=" 170px" vwidth=" 600px" orisrc="/__local/7/BD/96/80B4EFD367D5B0171BC0FB4220C_9C614755_51B8.gif" class="img_vsb_content"></a> 
 <a style="color: blue">
 <img alt=" " src="/__local/9/C8/30/9F5623FB19CBBD4C028B5B143F9_3A3C7588_DB2C.png?e=.png" style="width: 600px; float: none; height: 270px" vsbhref="vurl" vurl="/_vsl/9C8309F5623FB19CBBD4C028B5B143F9/3A3C7588/DB2C?e=.png" vheight=" 270px" vwidth=" 600px" orisrc="/__local/9/C8/30/9F5623FB19CBBD4C028B5B143F9_3A3C7588_DB2C.png?e=.png" class="img_vsb_content"></a> 
 
 <h1 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">2011, 3 以前（博士、博士后阶段的工作）</h1> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">5 <a href="http://pubmedcentralcanada.ca/pmcc/articles/PMC3418073/" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Lysine-functionalized nanodiamonds:synthesis, physiochemical characterization, and nucleic acid binding studies</a></h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">    Randeep Kaur, Jackson M Chitanda, DeborahMichel, Jason Maley, Ferenc Borondics, Peng Yang, Ronald E Verrall, IldikoBadea*. </h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">    Int. J. Nanomed. (IF, 4.383). 2012, 7, 3851</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">6   <a href="http://www.sciencedirect.com/science/article/pii/S0939641112000914" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Design and evaluation ofcyclodextrin-based dlivery systems to incorporate poorly soluble curcuminanalogs for the treatment of melanoma</a></h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">    Deborah Michel, Jackson M. Chitanda, RékaBalogh, Peng Yang, Jagbir Singh, Umashankar Das, Anas El-Aneed, JonathanDimmock, Ronald Verrall, Ildiko Badea*.</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">    Eur. J. Pharm. and Biopharm.(IF, 3.850).  2012, 81, 548</h3> 
 7  <a href="http://www.sciencedirect.com/science/article/pii/S0939641110001074" style="color: blue">Enhanced gene expression in epithelial cellstransfected with amino acid-substituted gemini nanoparticles</a> 
     Peng Yang,Jagbir Singh, Shawn Wettig, Marianna Foldvari, Ronald Verrall, IldikoBadea*. 
     Eur. J. Pharm. and Biopharm.(IF, 3.850). 2010, 75,  311 
 8    <a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.200805613/full" style="color: blue">Engineering Bisquinolinium/Thiazole Orange Conjugatesfor Fluorescent Sensing of G‐Quadruplex DNA</a> 
     Peng Yang,Anne De Cian, Marie-Paule Teulade-Fichou,* Jean-Louis Mergny*, David Monchaud. 
     Angew. Chem. Int. Ed. (IF, 11.261).  2009,48, 2188 
 9   <a href="http://onlinelibrary.wiley.com/doi/10.1002/ange.200800468/full" style="color: blue">A Metal‐Mediated Conformational Switch Controls G-QuadruplexBinding Affinity</a> 
      David Monchaud, Peng Yang, Laurent Lacroix,Marie-Paule Teulade-Fichou, Jean-Louis Mergny*. 
     Angew. Chem. Int. Ed. (IF, 11.261). 2008,47 , 4858 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">10  <a href="http://www.sciencedirect.com/science/article/pii/S0960894X08011761" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Naphthalimide intercalators withchiral amino side chains: Effects of chirality on DNA binding, photodamage andantitumor cytotoxicity</a></h3> 
     Qing Yang*,Peng Yang, Xuhong Qian*, Lianpeng Tong. 
     Bioorg. & Med. Chem. Lett. (IF, 2.420).  2008,18,6210 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">11  <a href="http://www.sciencedirect.com/science/article/pii/S1011134406000820" style="color: rgb(0,0,0); text-underline: none">Isoquino [4,5-bc] acridines: Design, synthesis and evaluation of DNA binding, anti-tumorand DNA photo-damaging ability</a></h3> 
     Peng Yang,Qing Yang, Xuhong Qian*, Lianpeng Tong, Xiaolian Li. 
     J. Photochem & Photobio.B: Biology (IF, 2.960). 2006, 84, 221 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">12  <a href="http://www.sciencedirect.com/science/article/pii/S0040402005016571" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Novel DNA bis-intercalators ofisoquinolino [4, 5-bc] acridines: design, synthesis and evaluation of cytotoxicactivity</a></h3> 
     Peng Yang,Qing Yang and Xuhong Qian*. 
     Tetrahedron(IF, 2.641).  2005, 61,11895 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">13 <a href="http://www.sciencedirect.com/science/article/pii/S0968089605006425" style="color: rgb(0,0,0); text-underline: none">Novelsynthetic isoquinolino [5, 4-ab] phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities</a></h3> 
     Peng Yang,Qing Yang, Xuhong Qian*, Jingnan Cui. 
      Bioorg.& Med. Chem. (IF,  2.793). 2005, 13, 5909 
 专利： 
 1.   新型环状寡聚咔唑衍生物及其制备方法与应用. 中国专利: 201510309211.8. （PCT专利：PCT/CN2015/099716）第一发明人 
 2.    噻唑橙衍生物及其制备和作为双螺旋核酸荧光分子探针的应用. 中国专利: 201310595094.7. 第一发明人 
 3.    一种以亚铜二甲硫醚配合物催化合成1,3-苯二胺衍生物的方法.中国专利: ZL201210402282.9. 第一发明人 
 4.   Drug DeliveryAgents Comprising Cyclodextrin Covalently Linked To A Gemini Sufactant AndPharmaceutical Compositions Comprising The Same. PCT专利: PCT/CA2012/000483;US9,168,306 B2) . 第三发明人 
 5   新型杂环并萘酰亚胺及双链化合物及其在肿瘤细胞中应用.中国专利: ZL200510026784.6. 第二发明人 
 <h2 style="text-align: justify">友情链接：</h2> 
 博士导师：       
 钱旭红　院士       
 <a href="http://pharmacy.ecust.edu.cn/s/48/t/73/a/11515/info.jspy" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://pharmacy.ecust.edu.cn/s/48/t/73/a/11515/info.jspy</a> 
 
 博士后合作导师： 
 Jean-louis Mergny   教授 
 <a href="http://www.iecb.u-bordeaux.fr/teams/MERGNY/Mergnys_Group/Welcome.html" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://www.iecb.u-bordeaux.fr/teams/MERGNY/Mergnys_Group/Welcome.html</a> 
 
 Marie-Paule Teulade-Fichou 教授 
 <a href="http://umr176.curie.fr/en/profile/marie-paule-teulade-fichou-00204" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://umr176.curie.fr/en/profile/marie-paule-teulade-fichou-00204</a> 
 
 Ronald E. Verrall    教授                       
 <a href="http://artsandscience.usask.ca/profile/RVerrall" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://artsandscience.usask.ca/profile/RVerrall</a> 
 
 Bruce C.Gibb         教授                     
 <a href="http://www2.tulane.edu/sse/chem/faculty/bruce-gibb.cfm" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://www2.tulane.edu/sse/chem/faculty/bruce-gibb.cfm</a> 
 
                               
 Curriculum Vitae（英文简历） Educational Background (教育及科研经历): 2011 - now:   Associate Professor, Principle Investigator,ShenYang Pharmaceutical University 
 2009 - 2010:  Postdoctor fellow, University of New Orleans, NewOrleans, LA, USA, Supervisor: Prof. Bruce C. Gibb 2007 - 2009: Postdoctor fellow, University of Saskatchewan,Saskatoon, SK, Canada, Supervisor: Prof. Ronald E. Verrall 2006 - 2007:Postdoctor researcher. The project was accomplished at twocollaborative labs: 1) Laboratoire de Biophysique, INSERM, Paris, France, Supervisor: Prof.Jean-louis Mergny 2) Laboratoire de Chimie des Interactions Moléculaires ( Jean-Marie Lehn’s Lab)- Collège de France, Paris, France: Supervisor: Dr. Marie-Paule Teulade-Fichou 2002 - 2006: Ph.D., Dalian University of Technology, Dalian, China,Supervisor: Prof. Xuhong Qian 1999 - 2002: M.S. Liaoning Shihua University, Fushun, China,Supervisor: Prof. Kejian Liao 1995 - 1999: B.S. Liaoning Shihua University, Fushun, China 
 
</div>

<div class="richContent"> 
 <h2 style="text-align: justify">课题组研究方向： </h2> 
 <h2 style="text-align: justify; text-indent: 37px">我们课题组多年来一直从事化学、生物学和药学等交叉学科研究工作，目前的兴趣是探索杯咔唑的化学生物学和药物化学。</h2> 
 <h2 style="text-align: justify; line-height: 150%; text-indent: 37px">理解小分子与生物学靶标之间相互作用的规律是上述研究中的核心问题，也是广义主客体化学的研究范畴。从最初的冠醚、环糊精，到目前的第三代主体分子杯芳烃、柱芳烃等，主客体化学至今已有近半世纪的历史。不断衍生的主体也丰富了客体的演化：从最初的阴阳离子，中性小分子到生物大分子。对后两者的识别和调控能力决定了主体分子成为药物载体以及先导药物分子的潜力。</h2> 
 <a style="line-height: 150%; font-family: 微软雅黑; color: rgb(102,102,102); font-size: 16px; font-weight: normal">
 <vsbimg alt=" " src="/_vsl/D37F13100EFDAD0D089225276C89CC9F/22166103/3F36?e=.jpg" style="width: 600px; float: none; height: 200px" vsbhref="vurl" vurl="/_vsl/D37F13100EFDAD0D089225276C89CC9F/22166103/3F36?e=.jpg" vheight=" 200px" vwidth=" 600px"></vsbimg></a> 
 
 <h3 style="text-justify: inter-ideograph; text-align: justify; margin-top: 10px; margin-bottom: 10px"></h3> 
 目前的杯芳烃大都基于苯酚骨架，受构像及尺寸大小等因素的限制，与生物大分子适配度不高。因此，尽管杯芳烃在材料等领域取得了巨大成功，在生物学以及药学等生命科学中的应用却步履蹒跚，进展缓慢。构建具有更大尺寸、更丰富构像、与生物大分子适配性能更好的新型杯芳烃，是该领域研究的重点与难点。鉴于此，我们课题组采用咔唑这一稠环芳烃为基本骨架，构建了空间结构更大、构像更加独特的新型大环分子（杯咔唑，见上图）。 
 <h3 style="text-justify: inter-ideograph; text-align: justify; margin-top: 10px; margin-bottom: 10px"> </h3> 
 
 <a style="color: blue">
 <vsbimg alt=" " src="/_vsl/0374FAE693E615DB6E96DED964328070/9ABA2847/4DFC?e=.jpg" style="width: 600px; float: none; height: 450px" vsbhref="vurl" vurl="/_vsl/0374FAE693E615DB6E96DED964328070/9ABA2847/4DFC?e=.jpg" vheight=" 450px" vwidth=" 600px"></vsbimg></a> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">与传统的大环（见上图）相比，杯咔唑构像的可调范围更宽。其丰富的构像可以通过调节寡聚数目得以实现。如下图所见，杯[3]咔唑可形成一端封闭的锥形结构，其体积与钾离子通道大小相当；杯[4]咔唑可以形成中空的、类纺线锤形状的构象；而杯[5]、杯[6]等更高寡聚度咔唑大环的构像更加独特，目前仍在探索中。</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">另外，构成这些大环基本单元的咔唑，其自身也有许多独特的性质：它即是性能优异的荧光团，被广泛应用于生产染料、颜料、光电导体、感光材料等；也是天然生物碱的母核，其抗菌和抗肿瘤活性近年来也逐渐被发现和报道。咔唑自身的这些光电及生物性能也赋予了杯咔唑更加广泛的应用空间，值得深入地挖掘和探索。</h3> 
 <a>
 <vsbimg alt=" " src="/_vsl/F22E1DF237EFBF1E58BB86F6AEB9C010/D1D77F0A/4A2A?e=.jpg" style="width: 600px; height: 550px" vsbhref="vurl" vurl="/_vsl/F22E1DF237EFBF1E58BB86F6AEB9C010/D1D77F0A/4A2A?e=.jpg" vheight=" 550px" vwidth=" 600px"></vsbimg></a> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; text-indent: 37px">当前，我们对杯咔唑的化学生物学研究主要聚焦于探索其模拟酶活性以及对核酸的识别和调控作用。通过我们的努力，我们期待杯咔唑能大放异彩，最终成为：1. 具有抗肿瘤活性的大分子类先导药物；2.增进难溶性药物生物利用度的小分子载体；3.活体检测疾病靶点的光学试剂。</h3> 
 <h2 style="text-align: justify">发表论文：</h2> 
 <h1 style="text-align: justify">2011,3－至今（入职沈阳药科大学后）</h1> 
 <h1 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 0px; margin-left: 40px">1   Engineering 1,3-Alternate Calixcarbazole forRecognition and Sensing of Bisphenol F in Water</h1> 
          <a href="http://pubs.acs.org/author/Li%2C+Gang" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Gang Li</a>, <a href="http://pubs.acs.org/author/Zhao%2C+Liang" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Liang Zhao</a>, <a href="http://pubs.acs.org/author/Yang%2C+Peng" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Peng Yang</a><a href="http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03398#cor1" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">*</a>, <a href="http://pubs.acs.org/author/Yang%2C+Zhaozheng" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Zhaozheng Yang</a>, <a href="http://pubs.acs.org/author/Tian%2C+Zhangmin" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Zhangmin Tian</a>, <a href="http://pubs.acs.org/author/Chen%2C+Yan" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Yan Chen</a>, <a href="http://pubs.acs.org/author/Shen%2C+Hongyan" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Hongyan Shen</a>, and <a href="http://pubs.acs.org/author/Hu%2C+Chun" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Chun Hu</a><a href="http://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03398#cor2" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">*</a> 
     Anal. Chem.(IF, 5.886)2016，DOI:10.1021/acs.analchem.6b03398 
       
 
 <vsbimg alt=" " src="/_vsl/98BB4D4B809417A59565DB5A31241593/B95E0ACF/AD32?e=.gif" width="500" height="281" vsbhref="vurl" vurl="/_vsl/98BB4D4B809417A59565DB5A31241593/B95E0ACF/AD32?e=.gif" vheight="281" vwidth="500"></vsbimg> 
     
 2    Calix[3]carbazole:One-Step Synthesis and Host–Guest Binding 
          PengYang*, Yong Jian, Xue Zhou, Gang Li, Tuo Deng, Hongyan Shen, Zhaozheng Yang,Zhangmin Tian. 
 J. Org. Chem. (IF, 4.721). 2016, 81, 2974 
                 
 
 <vsbimg alt=" " src="/_vsl/BDA3E83F5A36B6B34799F72A138BBB56/830CB3C3/3E2B?e=.gif" width="500" height="135" vsbhref="vurl" vurl="/_vsl/BDA3E83F5A36B6B34799F72A138BBB56/830CB3C3/3E2B?e=.gif" vheight="135" vwidth="500"></vsbimg> 
 
 3   <a href="http://www.sciencedirect.com/science/article/pii/S0925400514015500" style="color: blue">Adenosine triphosphateselective fluorescent turn-onresponse of anovel thiazole orange derivative via their cooperative co-assembly</a> 
     Tuo Deng,JianHui Chen, Hui Yu, Peng Yang*, Yong Jian, Gang Li, Xue Zhou, Hongyan Shen,Jianzhou Gui* 
     Sensors & Actuators B Chemical (IF, 4.758), 2015, 209, 735. 
       
 <a style="color: blue">
 <vsbimg alt=" " src="/_vsl/7254D6177B09CCCE3E0E61DC8B783FCE/BAEB6ED7/1BD17?e=.png" style="width: 600px; float: none; height: 400px" vsbhref="vurl" vurl="/_vsl/7254D6177B09CCCE3E0E61DC8B783FCE/BAEB6ED7/1BD17?e=.png" vheight=" 400px" vwidth=" 600px"></vsbimg></a> 
 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">4  <a href="http://www.sciencedirect.com/science/article/pii/S0040403914018528" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Synthesis of a novelmethylene-bridged biscarbazole derivative and evaluation of its DNA andnucleotide binding properties</a></h3> 
          GangLi, Xue Zhou, Peng Yang*, Yong Jian, Tuo Deng, Hongyan Shen, Ying Bao. 
     Tetrahedron Lett. (IF, 2.380) 2014, 55, 7054. 
   
        <a>
 <vsbimg alt=" " src="/_vsl/7BD9680B4EFD367D5B0171BC0FB4220C/9C614755/51B8?e=.gif" style="width: 600px; height: 170px" vsbhref="vurl" vurl="/_vsl/7BD9680B4EFD367D5B0171BC0FB4220C/9C614755/51B8?e=.gif" vheight=" 170px" vwidth=" 600px"></vsbimg></a> 
 <a style="color: blue">
 <vsbimg alt=" " src="/_vsl/9C8309F5623FB19CBBD4C028B5B143F9/3A3C7588/DB2C?e=.png" style="width: 600px; float: none; height: 270px" vsbhref="vurl" vurl="/_vsl/9C8309F5623FB19CBBD4C028B5B143F9/3A3C7588/DB2C?e=.png" vheight=" 270px" vwidth=" 600px"></vsbimg></a> 
 
 <h1 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">2011, 3 以前（博士、博士后阶段的工作）</h1> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">5 <a href="http://pubmedcentralcanada.ca/pmcc/articles/PMC3418073/" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Lysine-functionalized nanodiamonds:synthesis, physiochemical characterization, and nucleic acid binding studies</a></h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">    Randeep Kaur, Jackson M Chitanda, DeborahMichel, Jason Maley, Ferenc Borondics, Peng Yang, Ronald E Verrall, IldikoBadea*. </h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">    Int. J. Nanomed. (IF, 4.383). 2012, 7, 3851</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">6   <a href="http://www.sciencedirect.com/science/article/pii/S0939641112000914" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Design and evaluation ofcyclodextrin-based dlivery systems to incorporate poorly soluble curcuminanalogs for the treatment of melanoma</a></h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">    Deborah Michel, Jackson M. Chitanda, RékaBalogh, Peng Yang, Jagbir Singh, Umashankar Das, Anas El-Aneed, JonathanDimmock, Ronald Verrall, Ildiko Badea*.</h3> 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-bottom: 10px; margin-left: 40px">    Eur. J. Pharm. and Biopharm.(IF, 3.850).  2012, 81, 548</h3> 
 7  <a href="http://www.sciencedirect.com/science/article/pii/S0939641110001074" style="color: blue">Enhanced gene expression in epithelial cellstransfected with amino acid-substituted gemini nanoparticles</a> 
     Peng Yang,Jagbir Singh, Shawn Wettig, Marianna Foldvari, Ronald Verrall, IldikoBadea*. 
     Eur. J. Pharm. and Biopharm.(IF, 3.850). 2010, 75,  311 
 8    <a href="http://onlinelibrary.wiley.com/doi/10.1002/anie.200805613/full" style="color: blue">Engineering Bisquinolinium/Thiazole Orange Conjugatesfor Fluorescent Sensing of G‐Quadruplex DNA</a> 
     Peng Yang,Anne De Cian, Marie-Paule Teulade-Fichou,* Jean-Louis Mergny*, David Monchaud. 
     Angew. Chem. Int. Ed. (IF, 11.261).  2009,48, 2188 
 9   <a href="http://onlinelibrary.wiley.com/doi/10.1002/ange.200800468/full" style="color: blue">A Metal‐Mediated Conformational Switch Controls G-QuadruplexBinding Affinity</a> 
      David Monchaud, Peng Yang, Laurent Lacroix,Marie-Paule Teulade-Fichou, Jean-Louis Mergny*. 
     Angew. Chem. Int. Ed. (IF, 11.261). 2008,47 , 4858 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">10  <a href="http://www.sciencedirect.com/science/article/pii/S0960894X08011761" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Naphthalimide intercalators withchiral amino side chains: Effects of chirality on DNA binding, photodamage andantitumor cytotoxicity</a></h3> 
     Qing Yang*,Peng Yang, Xuhong Qian*, Lianpeng Tong. 
     Bioorg. & Med. Chem. Lett. (IF, 2.420).  2008,18,6210 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">11  <a href="http://www.sciencedirect.com/science/article/pii/S1011134406000820" style="color: rgb(0,0,0); text-underline: none">Isoquino [4,5-bc] acridines: Design, synthesis and evaluation of DNA binding, anti-tumorand DNA photo-damaging ability</a></h3> 
     Peng Yang,Qing Yang, Xuhong Qian*, Lianpeng Tong, Xiaolian Li. 
     J. Photochem & Photobio.B: Biology (IF, 2.960). 2006, 84, 221 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">12  <a href="http://www.sciencedirect.com/science/article/pii/S0040402005016571" style="line-height: 150%; font-family: 'Times New Roman','serif'; color: rgb(0,0,0); font-size: 16px; text-underline: none">Novel DNA bis-intercalators ofisoquinolino [4, 5-bc] acridines: design, synthesis and evaluation of cytotoxicactivity</a></h3> 
     Peng Yang,Qing Yang and Xuhong Qian*. 
     Tetrahedron(IF, 2.641).  2005, 61,11895 
 <h3 style="text-justify: inter-ideograph; text-align: justify; line-height: 150%; margin-left: 40px">13 <a href="http://www.sciencedirect.com/science/article/pii/S0968089605006425" style="color: rgb(0,0,0); text-underline: none">Novelsynthetic isoquinolino [5, 4-ab] phenazines: Inhibition toward topoisomerase I,antitumor and DNA photo-cleaving activities</a></h3> 
     Peng Yang,Qing Yang, Xuhong Qian*, Jingnan Cui. 
      Bioorg.& Med. Chem. (IF,  2.793). 2005, 13, 5909 
 专利： 
 1.   新型环状寡聚咔唑衍生物及其制备方法与应用. 中国专利: 201510309211.8. （PCT专利：PCT/CN2015/099716）第一发明人 
 2.    噻唑橙衍生物及其制备和作为双螺旋核酸荧光分子探针的应用. 中国专利: 201310595094.7. 第一发明人 
 3.    一种以亚铜二甲硫醚配合物催化合成1,3-苯二胺衍生物的方法.中国专利: ZL201210402282.9. 第一发明人 
 4.   Drug DeliveryAgents Comprising Cyclodextrin Covalently Linked To A Gemini Sufactant AndPharmaceutical Compositions Comprising The Same. PCT专利: PCT/CA2012/000483;US9,168,306 B2) . 第三发明人 
 5   新型杂环并萘酰亚胺及双链化合物及其在肿瘤细胞中应用.中国专利: ZL200510026784.6. 第二发明人 
 <h2 style="text-align: justify">友情链接：</h2> 
 博士导师：       
 钱旭红　院士       
 <a href="http://pharmacy.ecust.edu.cn/s/48/t/73/a/11515/info.jspy" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://pharmacy.ecust.edu.cn/s/48/t/73/a/11515/info.jspy</a> 
 
 博士后合作导师： 
 Jean-louis Mergny   教授 
 <a href="http://www.iecb.u-bordeaux.fr/teams/MERGNY/Mergnys_Group/Welcome.html" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://www.iecb.u-bordeaux.fr/teams/MERGNY/Mergnys_Group/Welcome.html</a> 
 
 Marie-Paule Teulade-Fichou 教授 
 <a href="http://umr176.curie.fr/en/profile/marie-paule-teulade-fichou-00204" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://umr176.curie.fr/en/profile/marie-paule-teulade-fichou-00204</a> 
 
 Ronald E. Verrall    教授                       
 <a href="http://artsandscience.usask.ca/profile/RVerrall" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://artsandscience.usask.ca/profile/RVerrall</a> 
 
 Bruce C.Gibb         教授                     
 <a href="http://www2.tulane.edu/sse/chem/faculty/bruce-gibb.cfm" style="line-height: 120%; font-family: 微软雅黑; color: blue; font-size: 12px; text-decoration: underline">http://www2.tulane.edu/sse/chem/faculty/bruce-gibb.cfm</a> 
 
                               
 Curriculum Vitae（英文简历） Educational Background (教育及科研经历): 2011 - now:   Associate Professor, Principle Investigator,ShenYang Pharmaceutical University 
 2009 - 2010:  Postdoctor fellow, University of New Orleans, NewOrleans, LA, USA, Supervisor: Prof. Bruce C. Gibb 2007 - 2009: Postdoctor fellow, University of Saskatchewan,Saskatoon, SK, Canada, Supervisor: Prof. Ronald E. Verrall 2006 - 2007:Postdoctor researcher. The project was accomplished at twocollaborative labs: 1) Laboratoire de Biophysique, INSERM, Paris, France, Supervisor: Prof.Jean-louis Mergny 2) Laboratoire de Chimie des Interactions Moléculaires ( Jean-Marie Lehn’s Lab)- Collège de France, Paris, France: Supervisor: Dr. Marie-Paule Teulade-Fichou 2002 - 2006: Ph.D., Dalian University of Technology, Dalian, China,Supervisor: Prof. Xuhong Qian 1999 - 2002: M.S. Liaoning Shihua University, Fushun, China,Supervisor: Prof. Kejian Liao 1995 - 1999: B.S. Liaoning Shihua University, Fushun, China 
 
</div>

0/0

网站首页 | 硕博招生 | 人才招聘 | 联系我们 | 学校首页